ืืงืฉืจ ืืื ืกืืื ืืืขื ืจืืืฉ
ืกืืื (SIBO) ืืืขื ืจืืืฉ ืื ืฉืชื ืชืืคืขืืช ืื ืกืืืคืืืืช ืฉืืชืจืืฉืืช ืืืขืจืืช ืืขืืืื, ืืื ืืืืืืช ืืืื ืืืื ืืืืื ืืืืคื ืืื ืืืื: ืืืื ืืื, ื ืคืืืืช, ืฉืืฉืืืื ืื ืขืฆืืจืืืืช, ืขืจืคืื ืืืื, ืืืืฉื, ืืขืืืช ืกืคืืื. ืืืจืืช ืืืืืื ืืื ืฉื ื ืืฆืืื ืืจืืืืชืืื ืืืื, ืืฉ ืืื ืืืจืืื ืฉืื ืื. ืกืืื (SIBO- Small Intestinal Bacterial Overgrowth) ืืืื ืืื ื ื ืชืกืืื ืช, ืืื ืืฆื ืคืชืืืืื ืฉื ืฉืืฉืื ืืชืจ ืฉื ืืืืืงืื ืืืขื ืืืง, ืืืืจืืื ืืชืกืืกืช ืืืื ืืื ืคืืืืช ืืืืจื. ืืขืืชืื ืกืืื ืืืื ืืืืืช ืืื ืชืกืืื ืื, ืืืืื ืืืื ืืืืื ืืชืืฆืืช ืืืืงืช ื ืฉืืคื ืืืื. ืกืืื ืืื ืืืจื ืคืืื ืฆืืืื ืืชืกืืื ืช ืืืขื ืืจืืืฉ, ืื ืื ืชืืื.
ืืขื ืจืืืฉ ืืืื ืืขืฆื ืชืกืืื ืช (ืืืกืฃ ืฉื ืชืกืืื ืื), ืฉืชืืื ืชืืื ืืขืืช ืชืกืืื ืื ืืืจืื ืืื ืื ืืืจืช ืืืืืื ืืืืจื ืืชืืฆืื ืืกืืื ืื ืืืืจืืื ืืืจืื. ืื ืืกืฃ, ืืฉืื ื ืืกืืื, ืชืกืืื ืช ืืืขื ืืจืืืฉ ืื ื ืืชื ืช ืืืืืื ืืืืฆืขืืช ืืืืงืช ืืขืืื, ืืื ืขื ืกืื ืฉืืืืช ืืคืจืขืืช ืขืืืื ืืืจืืช.
ืืื ืื ืืืื ืืจืื, ืฉืืืงื 50 ืืืงืจืื ืงืืื ืืื ืืืืขื ืืืกืงื ืืช ืืืืืช.
1. ืืืชืจ ืืฉืืืฉ ืืืกืืืืื ืืืขื ืจืืืฉ ืืืืื ื ืืืืืืืื ืื ืืกืืื (1).
2. ืืกืืืืื ืืชืกืืื ืช ืืืขื ืืจืืืฉ ืืฉ ืกืืืื ืคื 5 ืืคืชื ืกืืื, ืืืฉืจ ืืืืื ืฉืืื ื ืกืืืืื ืืืชืกืืื ืช (2).
ืืกืืืื, ืฉืชื ืืชืืคืขืืช ืืืืืืช ืืืืืช ื ืืืืืช ืืืื ืืืืฉืคืืข ืืืช ืขื ืืฉื ืื ืื ืื ืืืืจื.
ืืืืคืื ืืกืืื
ืกืืื ื ืืคื ืชืืช ืืืจืื ืจืืื ืืืชืจ ืฉื ืืืืฉื ืืืกืืืืืืก.
ืืืกืืืืืืก ืคืืจืืฉื ืืืกืจ ืืืืื ืฉื ืืืืืงืื, ืคืืจืืืช, ืคืจืืืืื ืืืืจืื ืืืืื ืืืจืื. ืืืืคืื ืฉืขืืื ืืืืกืืืืืืก, ืืจืื ืืขืืื ืื ืืกืืื.
ืืืืคืื ืืกืืื ืืฆืจืื ืืื ืืกืืื ืืช, ืงืืฆืืจื ืืจื ืื ืืขืืื ืืื. ืืฆืืื ืืจืืืช ืืืื ืืืืื ืืคืฉืจืืช, ืื ืืื ืืฆืจืืื ืฉืืืื ืฉื ืืื ืกืืื ืืืคืืืื ืืืงืืื ืฉื ืืชื ืื ืืขื ื ืื ืืืืกืืืืืืก ืขืฆืื, ืืื ืืฉืืคืืจ ืชืคืงืืื ืฉื ืืขืจืืช ืืขืืืื. ืืืืคืืืื ืฉื ืืงืจื ืืืงืฉืจ ืืกืืื ืื ืืฆืื ืืขืืืื ืืืืืื: ื ืืงืื ืจืขืืื, ืชืืื ื, ืืชืืืช ืคืจืืืืืืืงื, ืชืืกืคื ืชืืื ื ืืฆืืื ืืจืคื ืืืืืจื ืชื ืืขืชืืืช ืืขืืื ืืืคืจืฉืช ืืืฆื ืืจื ืืื ืื-ืืืงืจืืืืืืืื.
ืืื ืืื ืืฉ ืืช ืืืืงืจืืืืื ืืืืืืื ืฉืื. ืืืื ืืื ืืืคืื ืืื ืฉืืชืืื ืืืืื ืืืฉืื ืื ืงืื ืืืฉื ืืื ืืืืืืืืืืช.
ืคืจืืืืืืืงื ืืกืืื
ืื ืืชื ืืชืืืืืื ืขื ืกืืื, ืืื ืืฆื ืืื ืืฉืืืข ืื ืืขื ืืช ืืชืืืืจืื ืฉืืืขื ืช, ืฉื ืืืืช ืคืจืืืืืืืงื ืืกืืื ืื ืืืืืฆืช, ืืืืจ ืืืืืืจ ืืชืืคืขื ืฉืื ืืืืืงื ืืืขืืื ืื ืืื ืืฆืืืืช ืืชืจ, ืื ืืื ืืืืกืืฃ ืืฉ ืืืืืจื?
ืืชืืจ ืื ืฉืขืืงืืช ืืืจื ืืืืงืจ ืื ืืฉื ืื ืืืืคื ืฉืืืฃ, ืืฉืื ืื ืืขืืื ืืชืื ืฉืืชืืืืจืื ืืืืช ืื ืืืืืืงืช, ืืขืืืื ืืืจืื ืืื ืืคืกืคืก ืืื ืืืคืืื ืืขืื ืืืฉืื ืืกืืื, ืฉืืืื ืืืงืจืืช.
ืืกืคืจ ืืืงืจืื ืืืฉื ืื ืืืืจืื ืืช ืืฆืื ืฉื ืืืืช ืชืืกืคื ืคืจืืืืืืืงื ืืืื ืกืืื ืืืืื ืืฉืืคืืจ ืืชืกืืื ืื ืืชืืฆืืืช ืืขืืื (3). ืืขืืชืื ืืืืคืื ืืคืจืืืืืื ื ืืฆื ืืขืื ืืคืืื ืืืชืจ ืืืืคืื ืื ืืืืืืื (4).
ืืื ืื ืืืื ืฉืืืงื 18 ืืืงืจืื ืืืืขื ืืืกืงื ื ืฉืคืจืืืืืืืงื ืืขืงืืช ืฉืืฉืื ืืชืจ ืฉื ืืืืืงืื ืคืชืืื ืืื ืืจืืืื ืืืืื ืืืขื (ืืืืจื ืืขืืงืจื ืืืืื ืืกืืื) ืืืคืืืชื ืืืื ืืื (5) .
ืืืงืจ ืืขื ืืื ืืืจ ืืฆื, ืฉืืฉืคืขืช ืืคืจืืืืืืืงื ืืืงื ืืืชืจ ืืฆื ืื ืฉืืฆืื ืืืขื ืืจืืืฉ ืืฉืืื ืขื ืกืืื, ืืืฉืจ ืืฆื ืืกืืืืื ืืืขื ืจืืืฉ ืืื ืกืืื (6)
ืคืจืืืืืืืงื ืืื ืงืื ืืฉืืืืฉ ืืืืืื ืื ืื ืืืื ืืืืจื ืืื ืืืืฉื (7) ืืืฉ ืืคืืื ืืืชืจ ืืืงืจืื ืฉืืจืืื ืฉืืื ืืขืืื ืืื ืืืืคืื ืืืขื ืจืืืฉ.(8,9,10,11).
ืืืืื ืคืจืืืืืืืงื ืืืืืฅ ืืืฉืชืืฉ ืืกืืื?
ืงืืืืื ืืืคื ืืืฆืจืื ืคืจืืืืืืืื ืืฉืืง, ืจืืื ื ืืคืืื ืืชืื ืฉืืืฉืช ืืงืืืืจืืืช ืืืืื:
1. ืฉืืืืืื ืฉื ืืงืืืืฆืืืืก ืืืืคืืืืืงืืจืื
2. ืกืงืจืืืืืืก ืืืืจืื Saccharomyces boulardii
3. ืืฆืืืืก Bacillus
ืืืืงืจ ืืชืืื ืืืขื ืืจืืืฉ ืืืืข ืืืกืงื ื, ืฉืฉืืืื ืฉื ืฉืืืฉืช ืกืืื ืืคืจืืืืืืืงื ืืื ืืืคืงืืืืืช ืืืืชืจ ืืืืคืื ืืืขื ืจืืืฉ, ืืืืจ ืืื ืขืืืืื ืืื ืืฆืืจื ืกืื ืจืืืืช (12) (13).
ืืื ืขื ืืืช, ืืื ืกืื ืฉื ืกืืื ืืฉ ืืช ืืืืืืงืื ืืืืืื ืืกืคืฆืืคืืื ืฉืืขืืืื ืขืืืจื.
ืืืฉื, ืืืืืืง Lactobacillus plantrum LP-8 ื ืืฆื ืืื ืืขืื ืืืืคืื ืืกืืื ืืกืื ืืืื ืืืคืจืืชื. ืืืืืืงืื Bifidobacteria lactis HN019 ื Lactobacilus roterii 17938DSM ื ืืฆืื ืืขืืืื ืืืืคืื ืืกืืื ืืกืื ืืชืื.
ืืืฉืื ืืืืืจื ื ืืื ื ืฉื ืคืจืืืืืืืงื:
1. ืืฉืื ืืืืืจ ืืืฆืจืื ืฉื ืืืจืืช ืืคืืงืืืช, ืฉืขืืืืื ืืกืื ืืจืืืื ืืื ืืืืืืื ืืืืืฉืจืื ืืฉืจื ืืืจืืืืช.
2. ืชื ืื ืืืกืื ื ืืืชืื (GMP).
3. ืืคืืืช 10 ืืืืืจื CFU (ืืืฉืืืช ืฉื ืืืืืงืื).
4. ืชืืจืื ืชืคืืื ืืื ืฉืืืชืจ ืืจืื.
5. ืจืฆืื ืืืืืจ ืืืืฆืจ ืคืจืืืืืื ืืืขืื ื, ื ืืื ืืืืื.
ืืกืืืื, ืืืืคืื ืืกืืื, ืืฉืื ืืฉืื ืืกืืจืืืืืช ืืืคืื ืืจืืืช ืืืื ืืฉืืคืืจ ืืืฆื ืืืืื ืฉื ืืขืจืืช ืืขืืืื, ืืืืช, ืฉืื ืจืง ืฉืชืืื ืืจืืคืื ืืฉืืงืื ืืขืจืืช ืืขืืืื, ืืื ืื ืชืชืืื ืืืืคื ืจืื ืืื ืฉืืจ ืืขืจืืืช ืืืืฃ ืืชืฉืคืจ ืืช ืืืืืช ืืืืื.
ืืงืจืืื ื ืืกืคืช ืขื ืคืจืืืืืืืงื ืืงืืืงื ืืื
ืืงืืจืืช:
1. Chen B, Kim JJ, Zhang Y, Du L, Dai N. Prevalence and predictors of small intestinal bacterial overgrowth in irritable bowel syndrome: a systematic review and meta-analysis. J Gastroenterol. 2018 Jul;53(7):807-818.
2. Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, Sioulas A, Giamarellos-Bourboulis EJ, Triantafyllou K. Effect of a Preparation of FourProbiotics on Symptoms
of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019 Jun;11(2):627-634.
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